Osteoarthritic knee pain is worse with diabetes

  • Eitner A & al.
  • Arthritis Care Res (Hoboken)
  • 27 Feb 2020

  • curated by Kelli Whitlock Burton
  • Clinical Essentials
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Takeaway

  • Pain intensity from knee osteoarthritis was significantly higher in patients with diabetes, even after adjustment for age, BMI, and radiographic status.

Why this matters

  • This study may be the first to identify a link between arthritic knee pain level and diabetes.

Study design

  • Cross-sectional study on participants from osteoarthritis initiative was assessed.
  • Aged 45-79 years: with diabetes, n=202; without diabetes, n=2279.
    • Knee injury and Osteoarthritis Outcome Score (KOOS), numerical rating scale (NRS).
    • Medical Outcomes Study Short Form 12 (SF-12).
    • Center for Epidemiological Studies-Depression Scale (CES-D).
  • Funding: None.

Key results

  • Patients with vs without diabetes had worse scores (adjusted for BMI, osteoarthritis severity, age, and sex) on:
    • KOOS (β, −4.72; P<.001>
    • NRS (β, 0.42; P=.031).
    • SF-12 physical (β, −3.49; P<.001>
    • SF-12 mental health summary score (β, −1.42; P=.016).
    • CES-D (β, 1.08; P=.035).
  • Participants with diabetes were older (P=.032), had a higher BMI (P<.001 and had a higher comorbidity score>
  • In severe osteoarthritis (Kellgren and Lawrence grade scores, 4), differences of 11.1 points (KOOS; P=.014) and 2.5 points (NRS; P=.013) were recorded between the 2 groups.

Limitations

  • Self-reported data.
  • Between-group difference was attenuated when adjusting for confounders.