- Intra-articular corticosteroid injection (IACI) of betamethasone (eg, Celestone Soluspan) for knee osteoarthritis increases blood glucose, insulin, and insulin resistance in patients with type 2 diabetes (T2D).
Why this matters
- Clinicians prescribing IACI should be aware of and monitor its effects on metabolism in patients with T2D.
- Blood glucose (P=.004), insulin (P=.004), and insulin resistance (P=.003) were significantly higher than baseline at 1 day after IACI, and all returned to normal levels by day 8.
- Control patients did not show significant changes in blood glucose, insulin, or insulin resistance between baseline, day 1, and day 8.
- There were no significant differences in demographics between the control group and the treatment group.
- 10 patients with noninsulin-treated T2D and painful osteoarthritis were given IACI of 1 mL of depot betamethasone.
- Researchers measured fasting blood glucose and fasting blood insulin levels just before IACI and at 1 and 8 days after, and compared with age- and sex-matched control patients with T2D.
- Funding: None disclosed.
- Small sample size.