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In a Chinese randomized controlled trial (RCT) to evaluate pain relief in patients with osteoarthritis (OA), the depression medication duloxetine (Cymbalta), a serotonin-norepinephrine reuptake inhibitor, provided better pain relief than placebo.
Why this matters
More treatment options for OA pain are needed.
A 13-wk randomized, placebo-controlled, blinded, multicenter trial to evaluate safety and effectiveness of duloxetine 60 mg for chronic OA pain.
Knee or hip OA was diagnosed with American College of Rheumatology clinical and radiographic criteria.
Primary outcome was pain severity by Brief Pain Inventory 24-h Average Pain score.