- Women who received aspirin daily/almost daily for at least 6 months had 10% lower risk for ovarian cancer.
- Those who received acetaminophen almost daily for ≥6 months had a higher risk for serous ovarian cancer.
Why this matters
- Data available on the association between use of aspirin or other NSAIDs and risk for ovarian cancer are inconsistent.
- This study evaluated 758,829 women who reported analgesic use from 13 studies in the Ovarian Cancer Cohort Consortium.
- Daily/almost daily use, ≥6 days/week; frequent use, ≥4 days/week.
- Funding: Defense Ovarian Cancer Research Program, Breast Cancer Now, and the Institute of Cancer Research.
- 3514 women developed ovarian cancer.
- Women who reported daily/almost daily aspirin use had a lower risk for ovarian cancer (n=449; HR, 0.90; P=.05) vs infrequent/nonusers.
- Women who received aspirin daily/almost daily for 6 months to
- Daily acetaminophen use was associated with elevated risk for serous tumors (n=26; HR, 1.70; 95% CI, 1.14-2.55) vs infrequent/no use.
- Self-reported data.