- In patients with advanced ovarian cancer, interval cytoreduction with minimally invasive surgery (MIS) yields higher complete and optimal resection rates vs laparotomy after neoadjuvant chemotherapy (NACT).
- MIS was associated with less blood loss, lower transfusion rate, and shorter length of hospital stay.
Why this matters
- Findings warrant larger prospective trials to confirm the importance of MIS in advanced disease.
- 157 consecutive patients with stage III-IV epithelial ovarian, tubal, or peritoneal cancer underwent interval cytoreduction with MIS (n=53) or laparotomy (n=104) after at least 1 NACT cycle.
- Funding: None disclosed.
- Complete resection was achieved in 60.4% of patients in the MIS vs 42.3% in the laparotomy group.
- Optimal cytoreduction was achieved in 96.3% vs 82.7% of patients, respectively (P=.02).
- Patients undergoing MIS had significantly lower estimated blood loss (156 vs 278 mL; P<.001 fewer intraoperative transfusions vs p=".006)," and shorter hospital stay days>
- Operative time was significantly longer in the MIS group (171 vs 150 minutes; P=.007).
- No significant difference was observed in postoperative complications, ICU stay, readmission rates, PFS, or OS.
- Retrospective study.