Ovarian stimulation: serum LH levels predict response to GnRH trigger cycle

  • Popovic-Todorovic B & al.
  • Hum Reprod
  • 27 Sep 2019

  • International Clinical Digest
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Takeaway

  • Low levels of luteinising hormone (LH) at the initiation of ovarian stimulation are associated with suboptimal oocyte yield after gonadotropin-releasing hormone (GnRH), according to a retrospective study.

Why this matters

  • This study supports the predictive role of LH in response to GnRH and suggests LH levels should be measured before ovarian stimulation.

Key results

  • Mean oocyte yield was 89%.
  • Low LH levels on initiation of ovarian stimulation independently predicted suboptimal response in multivariate analysis (aOR, 0.920; 95% CI, 0.871-0.971).
  • Risk for suboptimal response decreased with increasing basal LH levels:
    • 45.2% for
    • 39.1% for
    • 25.2% for
    • 13.6% for
  • An LH cutoff of 5.39 IU/L had sensitivity of 53% and specificity of 65% for predicting suboptimal response.

Study design

  • 3334 patients who received GnRH agonist triggering with Triptorelin 0.2 mg were included.
  • Suboptimal response was defined as
  • Funding: None.

Limitations

  • Retrospective study design.

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