- Low levels of luteinising hormone (LH) at the initiation of ovarian stimulation are associated with suboptimal oocyte yield after gonadotropin-releasing hormone (GnRH), according to a retrospective study.
Why this matters
- This study supports the predictive role of LH in response to GnRH and suggests LH levels should be measured before ovarian stimulation.
- Mean oocyte yield was 89%.
- Low LH levels on initiation of ovarian stimulation independently predicted suboptimal response in multivariate analysis (aOR, 0.920; 95% CI, 0.871-0.971).
- Risk for suboptimal response decreased with increasing basal LH levels:
- 45.2% for
- 39.1% for
- 25.2% for
- 13.6% for
- An LH cutoff of 5.39 IU/L had sensitivity of 53% and specificity of 65% for predicting suboptimal response.
- 3334 patients who received GnRH agonist triggering with Triptorelin 0.2 mg were included.
- Suboptimal response was defined as
- Funding: None.
- Retrospective study design.