- For pain during labor, a median effective concentration (EC50) of 0.09687% ropivacaine combined with sufentanil 0.3 mg/mL or 18.76 μg epidural sufentanil combined with 0.1% ropivacaine yields a significant benefit without serious adverse events (AEs).
Why this matters
- Ropivacaine combined with low-dose sufentanil is the preferred drug for labor analgesia.
- The ideal concentration of either drug was unknown because previous studies have yielded conflicting results.
- Study of 60 women who received ropivacaine (0.1%) with sufentanil (0.3 mg/mL) for labor pain.
- Outcome: EC50 and visual analogue scale (VAS) scores.
- Funding: Shanghai Natural Science Foundation; others.
- The EC50 values for epidural administration:
- Ropivacaine: 0.09687% (95% CI, 0.08944%-0.1043%).
- Sufentanil: 18.76 μg (95% CI, 13.5-24.48 μg).
- Preanalgesia VAS scores were 8.13 for ropivacaine and 8.33 for sufentanil.
- These scores had significantly decreased at the following times (all P<.0001 style="list-style-type:circle;">
- 30 minutes after labor analgesia: 2.70 ropivacaine and 2.80 sufentanil.
- 60 minutes after labor analgesia: 1.37 ropivacaine and 1.53 sufentanil.
- Full dilation of cervix: 3.53 ropivacaine and 3.83 sufentanil.
- Fetal delivery: 2.80 ropivacaine vs 3.30 sufentanil.
- Nausea and vomiting: 16.7% with ropivacaine and 13.3% with sufentanil.
- Pruritus: 3.3% for each.
- Small sample size.
Coauthored with Chitra Ravi, MPharm