- Almost 30% of adult survivors of childhood cancer reported severe pain more than 20 years after their initial diagnosis.
Why this matters
- Regular pain screenings in survivors of childhood cancer could reduce the long-term effect of pain.
- 10,012 adult survivors and 3173 siblings from the Childhood Cancer Survivor Study.
- Follow-ups at 2 times, 5 years apart.
- Funding: National Cancer Institute.
- Compared with siblings, survivors were more likely to report (relative risks; 95% CIs):
- Severe or very severe pain: 1.28 (1.07-1.54).
- Quite a bit or extreme pain interference: 1.26 (1.06-1.51).
- Moderate or severe recurrent pain: 1.23 (1.02-1.49).
- At the second follow-up, compared with their siblings, survivors reported more:
- Symptoms of depression: 11.9% clinical vs 7.3% clinical (P<.001>
- Symptoms of anxiety: 7.8% clinical vs 5.7% clinical (P<.001>
- Total analgesic use: 11.7% vs 9.4% (P=.01).
- Severe late-occurrence pain: 1.47 (1.45-1.49).
- Quite a bit or extreme pain interference: 1.38 (1.35-1.41).
- Moderate or severe recurrent pain: 1.33 (1.32-1.34).
- Study design may have led to an underestimated effect of pain.