- A clinical practice guideline concludes that thyroid hormones have no relevant clinical benefit for patients with subclinical hypothyroidism (SCH).
Why this matters
- Thyroid hormones are increasingly prescribed, likely due to SCH; this recommendation may alter prescribing trends.
- The expert panel issued a strong recommendation against thyroid hormone in adults with SCH (elevated thyroid-stimulating hormone [TSH] levels with normal free thyroxine levels).
- This recommendation includes patients with no symptoms or nonspecific symptoms.
- This recommendation does not apply to women trying to become pregnant or patients with TSH >20 mIU/L.
- This recommendation may not apply to patients with severe symptoms or to young adults (≤30 years old).
- 21 trials with 2192 participants were included in a systematic review to develop the clinical practice guideline.
- The guideline panel included methodologists, general practitioners, internists, endocrinologists, and patient partners.
- Funding: None.
- Uncertainty about potential harms of thyroid hormone treatment.