Parkinson’s disease and risk for hip and non-vertebral fractures

  • Schini M & al.
  • Bone
  • 29 Nov 2019

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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Takeaway

  • The risk for hip and non-vertebral fractures was higher in patients with Parkinson’s disease (PD).

Why this matters

  • Findings suggest that patients with PD should have a fracture risk assessment in their standard care.

Study design

  • Meta-analysis included 18 studies (n=2,335,361) that compared the risk for fracture in patients with PD vs those without PD (control group).
  • Funding: Amgen Inc.

Key results

  • Compared with the control group, PD group was at an increased risk for hip (effect size [ES], 2.40; 95% CI, 2.04-2.82; I2, 87.4%) and non-vertebral (ES, 1.80; 95% CI, 1.60-2.01) fractures.
  • Men with PD (ES, 2.93; 95% CI, 2.05-4.18) were at an increased risk for hip fracture than women with PD (ES, 1.81; 95% CI, 1.61-2.04).
  • Similarly, the risk for non-vertebral fractures was higher in men with PD (ES, 2.26; 95% CI, 1.37-3.73) than women with PD (ES, 1.82; 95% CI, 1.33-2.48).
  • The study design, geographical region or diagnostic criteria for PD did not show any effects on fracture risk.

Limitations

  • Heterogeneity among studies.