- The risk for hip and non-vertebral fractures was higher in patients with Parkinson’s disease (PD).
Why this matters
- Findings suggest that patients with PD should have a fracture risk assessment in their standard care.
- Meta-analysis included 18 studies (n=2,335,361) that compared the risk for fracture in patients with PD vs those without PD (control group).
- Funding: Amgen Inc.
- Compared with the control group, PD group was at an increased risk for hip (effect size [ES], 2.40; 95% CI, 2.04-2.82; I2, 87.4%) and non-vertebral (ES, 1.80; 95% CI, 1.60-2.01) fractures.
- Men with PD (ES, 2.93; 95% CI, 2.05-4.18) were at an increased risk for hip fracture than women with PD (ES, 1.81; 95% CI, 1.61-2.04).
- Similarly, the risk for non-vertebral fractures was higher in men with PD (ES, 2.26; 95% CI, 1.37-3.73) than women with PD (ES, 1.82; 95% CI, 1.33-2.48).
- The study design, geographical region or diagnostic criteria for PD did not show any effects on fracture risk.
- Heterogeneity among studies.