- This meta-analysis suggests that men with Parkinson’s disease (PD) are more likely to experience sexual dysfunction (SD) than those without PD.
- Association between PD and SD is non-significant in women.
Why this matters
- Findings suggest that patients with PD should be routinely assessed for sexual functioning, especially men.
- After a search across electronic databases, 11 observational studies involving 30,150 patients with PD and healthy control individuals (mean age 54.6-75.1 years) met eligibility criteria.
- Funding: The Science and Technology Planning Project of Guangdong Province.
- The pooled results of 7 studies revealed that men with PD were at increased risk for SD vs the control group (relative risk [RR], 1.79; P=.001; I2, 73.2%).
- There was no significant association between PD and SD in women (3 studies; RR, 1.3; P=.469; I2, 80.0%).
- The pooled results of 3 studies showed a positive association between PD and SD (RR, 1.74; P=.004)
- The GRADE profiler showed that the overall quality of the evidence was low in studies including men and very low in studies including women.
- Heterogeneity among included studies.
- Stratification analyses based on disease duration not performed.