- Smoking cessation may be a modifiable risk factor for impaired QoL in patients with multiple sclerosis (MS).
Why this matters
- Characterization of US patients with MS who are active smokers may help inform interventions.
- Overall, 11% of patients were current smokers, averaging 13.4 cigarettes daily.
- Smokers had lower scores for health-related QoL (P<.001) and more disease activity (P<.05) and greater deficits in all Performance Scales and Functional Scales (P<.001 to .05) except for mobility.
- Smokers had greater disability as assessed with the item response theory measure (P<.001).
- Smokers were more likely to have had a relapse in the past 6 mo (adjusted OR, 1.66).
- A cross-sectional survey of 950 US patients from the North American Research Committee on Multiple Sclerosis registry.
- The main outcomes were health-related QoL (Short Form-12), disease activity (8 Performance Scales and 3 Functionality Scales), and global disability (Patient Determined Disease Steps and an item response theory summed score based on the Performance and Functionality Scales).
- Funding: NIH.
- The direction of association is unknown.
- The cohort was largely non-Hispanic white.
- Findings may have been affected by residual confounding.