- A cross-sectional study suggests that serum anti-Mullerian hormone (AMH) levels and the luteinizing hormone (LH)/follicle stimulating hormone (FSH) ratio have similar diagnostic performance for PCOS.
Why this matters
- PCOS diagnosis is challenging, and the best diagnostic method is unclear.
- At the optimum cutoff of 32.79 pmol/L, AMH had sensitivity of 78.50%, specificity of 75.83%, and area under the curve of 0.852 (95% CI, 0.826-0.875).
- 1 ng/mL increase in AMH was associated with increased risk for PCOS (OR, 1.63; P<.001>
- At the optimum cutoff of 1.33, the LH/FSH ratio had sensitivity of 65.76%, specificity of 95.24%, and area under the curve of 0.867 (95% CI, 0.842-0.889).
- 1 unit increase in LH/FSH ratio was associated with increased risk for PCOS (OR, 14.433; P<.001>
- AMH and LH/FSH ratio had similar diagnostic value (P=.340 and P=.897 in 2 different types of analysis).
- Vietnamese multicenter study of 863 infertile women between 18 and 45 years old (441 with PCOS and 422 without).
- Funding: None.
- Results limited to a single ethnic group and narrow age range.