PCOS: AMH levels, LH/FSH ratio show similar diagnostic value

  • Le MT & al.
  • Clin Endocrinol (Oxf)
  • 13 Jan 2019

  • curated by Brian Richardson, PhD
  • Clinical Essentials
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • A cross-sectional study suggests that serum anti-Mullerian hormone (AMH) levels and the luteinizing hormone (LH)/follicle stimulating hormone (FSH) ratio have similar diagnostic performance for PCOS.

Why this matters

  • PCOS diagnosis is challenging, and the best diagnostic method is unclear.

Key results

  • At the optimum cutoff of 32.79 pmol/L, AMH had sensitivity of 78.50%, specificity of 75.83%, and area under the curve of 0.852 (95% CI, 0.826-0.875).
    • 1 ng/mL increase in AMH was associated with increased risk for PCOS (OR, 1.63; P<.001>
  • At the optimum cutoff of 1.33, the LH/FSH ratio had sensitivity of 65.76%, specificity of 95.24%, and area under the curve of 0.867 (95% CI, 0.842-0.889).
    • 1 unit increase in LH/FSH ratio was associated with increased risk for PCOS (OR, 14.433; P<.001>
  • AMH and LH/FSH ratio had similar diagnostic value (P=.340 and P=.897 in 2 different types of analysis).

Study design

  • Vietnamese multicenter study of 863 infertile women between 18 and 45 years old (441 with PCOS and 422 without).
  • Funding: None.

Limitations

  • Results limited to a single ethnic group and narrow age range.

Please confirm your acceptance

To gain full access to GPnotebook please confirm:

By submitting here you confirm that you have accepted Terms of Use and Privacy Policy of GPnotebook.

Submit