- Elevated fasting insulin is associated with increased cardiovascular (CV) and metabolic risk factors in people with polycystic ovary syndrome (PCOS) compared with control subjects.
Why this matters
- The influence of insulin concentration on PCOS pathogenesis is poorly understood.
- Patients with PCOS had higher fasting insulin levels, weight, body mass index (BMI), waist-hip ratio (WHR), and Ferriman-Gallwey (FG) score compared with control subjects (P<.01 for all>
- In patients with PCOS, fasting insulin was positively correlated with BMI (P<.001 whr waist-height ratio glucose fasting free androgen index fg score testosterone homeostasis model assessment-estimated insulin resistance ir p and lipid accumulation product negatively correlated with quantitative sensitivity check>
- In control subjects, fasting insulin was positively correlated with WHR (P<.05 testosterone homa ir and lap negatively correlated with fg score quicki>
- 249 patients with PCOS and 100 age-matched control subjects were analyzed for fasting insulin and CV/metabolic risk factors.
- Funding: Indian Council of Medical Research.
- Measurements only taken at a single point.