PCOS: high fasting insulin marks cardiovascular and metabolic risk

  • Rasool SUA & al.
  • Diabetes Metab Syndr

  • International Clinical Digest
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Takeaway

  • Elevated fasting insulin is associated with increased cardiovascular (CV) and metabolic risk factors in people with polycystic ovary syndrome (PCOS) compared with control subjects.

Why this matters

  • The influence of insulin concentration on PCOS pathogenesis is poorly understood.

Key results

  • Patients with PCOS had higher fasting insulin levels, weight, body mass index (BMI), waist-hip ratio (WHR), and Ferriman-Gallwey (FG) score compared with control subjects (P<.01 for all>
  • In patients with PCOS, fasting insulin was positively correlated with BMI (P<.001 whr waist-height ratio glucose fasting free androgen index fg score testosterone homeostasis model assessment-estimated insulin resistance ir p and lipid accumulation product negatively correlated with quantitative sensitivity check>
  • In control subjects, fasting insulin was positively correlated with WHR (P<.05 testosterone homa ir and lap negatively correlated with fg score quicki>

Study design

  • 249 patients with PCOS and 100 age-matched control subjects were analyzed for fasting insulin and CV/metabolic risk factors.
  • Funding: Indian Council of Medical Research.

Limitations

  • Measurements only taken at a single point.

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