PCOS: hormonal, metabolic features linked to pregnancy outcomes

  • Christ JP & al.
  • J Clin Endocrinol Metab
  • 24 Dec 2018

  • curated by Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Analysis of 2 prospective cohort studies suggests that preconception disease characteristics, including free androgen index, fasting glucose, fasting insulin, and testosterone levels, are associated with obstetric and perinatal complications in women with polycystic ovary syndrome (PCOS).

Why this matters

  • Better understanding of risk factors can help guide patient management.

Key results

  • Multiple-gestation pregnancy (OR, 5.9; P<.001 smoking status testosterone and fasting insulin were associated with adverse outcomes.>
  • Multiple-gestation pregnancy (OR, 2.9; P=.020), free androgen index (OR, 1.1; P=.020), and diastolic BP (OR, 1.1; P<.001 were associated with preeclampsia.>
  • Multiple-gestation pregnancy (OR, 13.2; P<.001 testosterone estrogen and fasting glucose were associated with preterm delivery.>
  • Small for gestational age was associated with smoking status (OR, 2.0; P<.001 and bmi>
  • Low Apgar score was associated with multiple-gestation pregnancy (OR, 2.6; P=.008) and oligo-amenorrhea (OR, 0.2; P<.001>

Study design

  • 1715 women with PCOS who became pregnant and had a live birth after screening were included.
  • Funding: Fulbright US Student Association; Dutch Heart Foundation.

Limitations

  • No analyses of pregnancy-induced hypertension or gestational diabetes.

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