PCOS linked to poor bone health in meta-analysis

  • Piovezan JM & al.
  • Hum Reprod Update
  • 2 Aug 2019

  • International Clinical Digest
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Takeaway

  • Polycystic ovary syndrome (PCOS) is associated with reduced spine bone mineral density (BMD) and bone formation in women with body mass index (BMI) 2, according to a systematic review and meta-analysis.

Why this matters

  • The association between PCOS and bone health is controversial, necessitating clarification.

Key results

  • Women with PCOS and BMI 2 had lower total femur BMD (mean difference [MD], −0.037; P=.043) compared with control subjects; no significant difference was found for women with PCOS and BMI ≥27 kg/m2.
  • Women with PCOS and BMI 2 had lower total spine BMD (MD, −0.069; 95% CI, −0.013 to −0.005 compared with control subjects); women with PCOS and BMI ≥27 kg/m2 had higher spine BMD (MD, 0.025; P=.031).
  • Women with PCOS and BMI 2 had lower levels of osteocalcin (standardized MD, −2.683; 95% CI, −4.702 to −0.665) compared with control subjects; no significant difference was found for women with PCOS and BMI ≥27 kg/m2.
  • Risk for fracture was higher in patients with PCOS (HR, 1.109; P<.0001>

Study design

  • 21 studies (31,383 women with PCOS and 102,797 control subjects) were included in the meta-analysis.
  • Funding: None.

Limitations

  • Few studies included bone fractures as an end point.