PCOS: surrogate estimates accurately mark insulin resistance

  • Dahan MH & al.
  • J Endocrinol Invest
  • 30 Jan 2019

  • curated by Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • A retrospective study suggests that surrogate estimates of insulin resistance (IR) are significantly associated with direct measurements in women with PCOS.

Why this matters

  • Estimates account for about 50% of IR variability in women with PCOS; direct measurements of insulin are labor intensive.

Key results

  • Surrogate estimates were significantly correlated with steady-state plasma glucose (SSPG) in women with PCOS:
    • r=0.26 (P=.02) for fasting plasma glucose (FPG).
    • r=0.76 (P=.0001) for fasting plasma insulin (FPI).
    • r=0.74 (P=.0001) for FPG/FPI.
    • r=0.80 (P=.0001) for homeostasis model assessment of insulin status (HOMA-IR).
    • r=0.76 (P=.0001) for quantitative insulin sensitivity check index (QUICKI).
  • These surrogate estimates were also significantly correlated in control subjects (P≤.001 for all).
  • FPG was not significantly associated with SSPG in women with PCOS and BMI ≥30 kg/m2 (P=.52) or control participants with BMI kg/m2 (P=.74).
  • FPG/FPI was not significantly associated with SSPG in women with PCOS and BMI kg/m2 (P=.06).

Study design

  • 75 women with PCOS and 118 control subjects were analyzed for correlations between surrogate estimates of insulin resistance and direct measurements.
  • Funding: Women’s Reproductive Health Research Scholars program; NIH through the Eunice Kennedy Shriver National Institute of Child Health and Human Development.

Limitations

  • Retrospective study.
  • Small patient sample size.