- A retrospective study suggests that surrogate estimates of insulin resistance (IR) are significantly associated with direct measurements in women with PCOS.
Why this matters
- Estimates account for about 50% of IR variability in women with PCOS; direct measurements of insulin are labor intensive.
- Surrogate estimates were significantly correlated with steady-state plasma glucose (SSPG) in women with PCOS:
- r=0.26 (P=.02) for fasting plasma glucose (FPG).
- r=0.76 (P=.0001) for fasting plasma insulin (FPI).
- r=−0.74 (P=.0001) for FPG/FPI.
- r=−0.80 (P=.0001) for homeostasis model assessment of insulin status (HOMA-IR).
- r=0.76 (P=.0001) for quantitative insulin sensitivity check index (QUICKI).
- These surrogate estimates were also significantly correlated in control subjects (P≤.001 for all).
- FPG was not significantly associated with SSPG in women with PCOS and BMI ≥30 kg/m2 (P=.52) or control participants with BMI kg/m2 (P=.74).
- FPG/FPI was not significantly associated with SSPG in women with PCOS and BMI kg/m2 (P=.06).
- 75 women with PCOS and 118 control subjects were analyzed for correlations between surrogate estimates of insulin resistance and direct measurements.
- Funding: Women’s Reproductive Health Research Scholars program; NIH through the Eunice Kennedy Shriver National Institute of Child Health and Human Development.
- Retrospective study.
- Small patient sample size.