PCOS tied to years earlier onset of metabolic syndrome

  • J Clin Endocrinol Metab

  • curated by Elisabeth Aron, MD, MPH, FACOG
  • Clinical Essentials
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Takeaway

  • Women with PCOS may develop metabolic syndrome earlier than women without PCOS.

Why this matters

  • PCOS affects 6%-10% of reproductive-aged women.
  • Early screening and weight loss may help reduce risk of metabolic syndrome in women with PCOS.

Key results

  • 11.7% of sample was diagnosed as PCOS-like.
  • 26.4% of women were obese, and 15.3% were diagnosed with metabolic syndrome.
  • After adjusting for confounders, diagnosis of PCOS-like increased risk for metabolic syndrome (risk ratio, 1.21; 95% CI, 0.91-1.51) between the ages of 40 and 50 years.
  • Metabolic syndrome occurred 2.8 years earlier in women with PCOS-like status compared with women without PCOS.

Study design

  • Prospective population-based cohort study.
  • Cohort obtained from the Michigan Bone Health and Metabolism Study, a longitudinal cohort study looking at reproductive health through menopause (n=496).
  • Women with PCOS-like cases were identified if they met 2 of 3 criteria: irregular menstrual cycles, chemical hyperandrogenism, high anti-Mullerian hormone at ≥2 visits (n=58 women in final analysis).
  • Metabolic syndrome was identified using the Adult Treatment Panel III Criteria.
  • Funding: National Institute of Arthritis and Musculoskeletal and Skin Diseases. 

Limitations

  • Racial/ethnic disparities not addressed in this study.
  • Inability to make a clinical diagnosis of PCOS; used PCOS-like diagnosis only.

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