- Women with PCOS may develop metabolic syndrome earlier than women without PCOS.
Why this matters
- PCOS affects 6%-10% of reproductive-aged women.
- Early screening and weight loss may help reduce risk of metabolic syndrome in women with PCOS.
- 11.7% of sample was diagnosed as PCOS-like.
- 26.4% of women were obese, and 15.3% were diagnosed with metabolic syndrome.
- After adjusting for confounders, diagnosis of PCOS-like increased risk for metabolic syndrome (risk ratio, 1.21; 95% CI, 0.91-1.51) between the ages of 40 and 50 years.
- Metabolic syndrome occurred 2.8 years earlier in women with PCOS-like status compared with women without PCOS.
- Prospective population-based cohort study.
- Cohort obtained from the Michigan Bone Health and Metabolism Study, a longitudinal cohort study looking at reproductive health through menopause (n=496).
- Women with PCOS-like cases were identified if they met 2 of 3 criteria: irregular menstrual cycles, chemical hyperandrogenism, high anti-Mullerian hormone at ≥2 visits (n=58 women in final analysis).
- Metabolic syndrome was identified using the Adult Treatment Panel III Criteria.
- Funding: National Institute of Arthritis and Musculoskeletal and Skin Diseases.
- Racial/ethnic disparities not addressed in this study.
- Inability to make a clinical diagnosis of PCOS; used PCOS-like diagnosis only.