- A single, intraoperative dose of dexamethasone significantly reduced infectious complications after pancreaticoduodenectomy (PD, also known as a Whipple procedure), and was associated with a significant OS advantage in patients with pancreatic ductal adenocarcinoma (PDAC).
Why this matters
- The effect of dexamethasone and other corticosteroids on healing after PD was unclear.
- 679 patients with pancreatic cancer underwent PD with (n=117) or without (n=562) intraoperative dexamethasone.
- Funding: None disclosed.
- Rate of overall complications was similar between groups (59.0% in dexamethasone group vs 62.8% in control group; P=.346).
- Dexamethasone was associated with both significantly fewer infectious complications (18.8% vs 28.5%; P=.032) and a trend toward lower incidence of postoperative sepsis that failed to achieve significance (2.6% vs 7.3%; P=.059).
- Median OS was significantly higher with dexamethasone (46 vs 22 months; P=.017).
- In multivariate analysis, dexamethasone was significantly associated with better OS (HR, 0.57; 95% CI, 0.37-0.87).
- Retrospective study.