- Fatty acid (FA) intake may modulate asthma severity in school-aged children, as well as their response to particulate matter (PM) indoor air pollution.
- Editorial calls for intervention trials.
Why this matters
- Low-income minority children in inner cities have disproportionately high asthma rates and tend to eat typical Western diets low in anti-inflammatory omega-3 FAs and high in pro-inflammatory omega-6.
- Children with asthma spend most time indoors, exposed to PM.
- Mean age, 9.5 years.
- On multivariate analysis, each additional gram of omega-6 intake correlated with:
- Higher likelihood of more severe asthma: OR, 1.29; P=.02.
- Lower FEV1/FVC: P=.01.
- Association between PM2.5 and daytime symptoms was:
- Strengthened with each additional gram of omega-6 intake: OR, 1.02/g; P<.01.>
- Weakened with each additional 0.1 g of omega-3 intake: OR, 0.96/0.1 g increase in omega-3; P<.01.>
- Prospective 6-month cohort AsthmaDIET Study (n=135).
- Participants: Baltimore children aged 5-12 years with asthma.
- Researchers assessed indoor particulate pollution levels, FA intake.
- Outcome: asthma severity, symptoms.
- Funding: NIH; Environmental Protection Agency.
- Small study, small effect sizes.
- PM sources not assessed.