Pediatric asthma: omega-3 and -6 intake linked to severity, particulate response

  • Brigham EP & al.
  • Am J Respir Crit Care Med
  • 29 Mar 2019

  • International Clinical Digest
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Fatty acid (FA) intake may modulate asthma severity in school-aged children, as well as their response to particulate matter (PM) indoor air pollution.
  • Editorial  calls for intervention trials.

Why this matters

  • Low-income minority children in inner cities have disproportionately high asthma rates and tend to eat typical Western diets low in anti-inflammatory omega-3 FAs and high in pro-inflammatory omega-6.
  • Children with asthma spend most time indoors, exposed to PM.

Key results

  • Mean age, 9.5 years.
  • On multivariate analysis, each additional gram of omega-6 intake correlated with:
    • Higher likelihood of more severe asthma: OR, 1.29; P=.02.
    • Lower FEV1/FVC: P=.01.
  • Association between PM2.5 and daytime symptoms was:
    • Strengthened with each additional gram of omega-6 intake: OR, 1.02/g; P<.01.>
    • Weakened with each additional 0.1 g of omega-3 intake: OR, 0.96/0.1 g increase in omega-3; P<.01.>
  • Similar relationship between PM10 and daytime symptoms for both FA types.
  • Similar relationship between PM10 and nighttime symptoms for omega-6.

Study design

  • Prospective 6-month cohort AsthmaDIET Study (n=135).
  • Participants: Baltimore children aged 5-12 years with asthma.
  • Researchers assessed indoor particulate pollution levels, FA intake. 
  • Outcome: asthma severity, symptoms.
  • Funding: NIH; Environmental Protection Agency.

Limitations

  • Small study, small effect sizes.
  • PM sources not assessed.

Please confirm your acceptance

To gain full access to GPnotebook please confirm:

By submitting here you confirm that you have accepted Terms of Use and Privacy Policy of GPnotebook.

Submit