- A comprehensive lead-hazard intervention reduced lead exposure without increasing body lead burden among children but failed to improve most neurobehavioral outcomes.
Why this matters
- Intervention reduced dust lead load by 24% for floors, 40% for windowsills, and 47% for window troughs.
- Compared with control, intervention reduced blood lead concentration by 6% among children overall (P=.29) and by 31% among children of non-Hispanic black women (P=.02).
- There was no significant difference on most neurobehavioral test scores.
- Exception was lower anxiety scores in intervention group (β, –1.6; P=.04).
- Editorialist: “More targeted and ambitious lead policy could be a pivotal element of broader social policy to address the environmental legacy of structural racism and thereby close racial gaps in achievement, behavior, and well-being.”
- Longitudinal, community-based randomized controlled trial of pregnant women and their children (metropolitan Cincinnati; HOME Study).
- 355 pregnant women randomly assigned to residential lead-reducing intervention or control intervention.
- Main outcomes: dust lead load, blood lead concentration, neurobehavioral outcomes up to 8 years of age.
- Funding: National Institutes of Environmental Health Sciences; others.
- Only some children were at high risk.
- Certain subgroups were small.
- Nonresidential lead was not addressed.