People with comorbid depression and diabetes are at higher risk for cardiovascular mortality and stroke

  • Farooqi A & al.
  • Diabetes Res Clin Pract
  • 14 Aug 2019

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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Takeaway

  • This meta-analysis suggests an associated increased risk for cardiovascular mortality and stroke in people with comorbid depression and type 2 diabetes (T2D).

Why this matters

  • Findings provide further insight into the increased risk for cardiovascular outcomes in people with T2D and depression.

Study design

  • Meta-analysis of 9 studies involving 346,037 patients with T2D and depression and 614,574 patients with diabetes only (mean age, 60.4 years; mean follow-up duration, 8.3 years).
  • Funding: None.

Key results

  • Patients with depression and T2D vs those with T2D alone showed significant association with:
    • cardiovascular mortality (HR, 1.48; 95% CI, 1.185-1.845; I2=43.4%; P=.001),
    • coronary heart disease (HR, 1.37; 95% CI, 1.165-1.605; I2=15%; P<.001 and>
    • stroke (HR, 1.33; 95% CI, 1.291-1.369; I2=84.7%; P<.001>
  • Depression in patients with T2D was not significantly associated with mean age, duration of diabetes, length of follow-up, body mass index, sex and ethnicity (all P<.05>

Limitations

  • Heterogeneity among included studies.