- Results of a meta-analysis show that pulmonary hypertension (PH) affects 1 in 5 patients undergoing peritoneal dialysis.
Why this matters
- Prior research has focused primarily on PH in hemodialysis; this is the first meta-analysis to quantify prevalence in peritoneal dialysis.
- Meta-analysis of 14 observational studies (n=1483) gleaned from PubMed, EMBASE, the Cochrane Collaboration, and reference lists of relevant articles.
- 5 prospective, 5 retrospective, and 4 cross-sectional studies were included from China (3), Saudi Arabia (2), Turkey (2), Iran (2), Israel (1), and the U.S. (1).
- Study population ranged from 5 to 618 patients; mean age, 41.7-73.4 years.
- Funding: None.
- Pooled prevalence of PH was 21% (95% CI, 16%-28%) using a random-effects model.
- Heterogeneity was high (I2=84%; P<.01 potentially driven by region sample size and publication year.>
- Prevalence was supported in sensitivity analysis; omission of any 1 study changed the estimates between 20% (95% CI, 14%-27%) and 23% (95% CI, 17%-30%).
- Egger’s test showed no significant bias (P=.287).
- Across 9 studies with available data, pooled prevalence of PH in hemodialysis was 36% (95% CI, 27%-48%).
- Pulmonary artery systolic pressure measured by echocardiogram.
- Very small sample size in some studies.