Pharynx SCC: FDG-PET quantitative parameters predict PFS in Japanese study

  • Fujima N & al.
  • Clin Radiol
  • 21 Sep 2018

  • curated by Brian Richardson, PhD
  • Univadis Clinical Summaries
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Takeaway

  • A retrospective analysis concludes that the 2-[18F]-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) quantitative parameters of homogeneity and sphericity are associated with PFS of patients with pharynx squamous cell carcinoma (SCC).

Why this matters

  • This study lends support to the use of a tumor’s 3D shape on FDG-PET for predicting treatment outcomes.

Key results

  • Higher homogeneity and sphericity were associated with improved PFS (HR, 1.76 [P=.02] and 2.71 [P=.01], respectively) in multivariate analysis.
    • This result was confirmed in Kaplan-Meier analysis (P=.01 for homogeneity and P=.002 for sphericity).
  • A cutoff value of 0.37 for homogeneity was associated with sensitivity of 91%, specificity of 58%, positive predictive value (PPV) of 80%, negative predictive value (NPV) of 78%, and accuracy of 79% for PFS.
  • A cutoff value of 0.35 for sphericity was associated with sensitivity of 74%, specificity of 94%, PPV of 96%, NPV of 67%, and accuracy of 81% for PFS.
  • Patients with high homogeneity (≥0.37) and high sphericity (≥0.35) had longer PFS than patients with either high homogeneity or high sphericity, who had longer PFS than patients with both low homogeneity (
  • No analyzed parameter was significantly associated with OS.

Study design

  • 54 patients with pharynx SCC were analyzed for 14 FDG-PET parameters to identify associations with survival outcomes.
  • Funding: None disclosed.

Limitations

  • Small patient sample size.
  • Retrospective study.

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