- For patients with Parkinson disease and depression, 10 weekly sessions of tailored telephone-based cognitive-behavioral therapy (CBT) targeting negative thoughts and engaging their caregivers reduced depression vs treatment as usual.
Why this matters
- Compared with treatment as usual, telephone-based CBT significantly improved depression scores by end of the treatment: 6.53 points vs −0.27 points (P<.0001>
- Benefit persisted over the 6-month follow-up (P<.0001>
- Difference was driven by a reduction in negative thoughts seen only in the telephone-based CBT group.
- Additional benefits with telephone-based CBT vs treatment as usual:
- Reduced anxiety (P<.0001>
- Better QoL (P=.007).
- Randomized controlled trial, 72 patients with Parkinson disease and depressive disorder and without dementia (mean age, 65.22 years).
- Patients had either tailored telephone-based CBT (weekly for 3 months then, optionally, monthly during 6-month follow-up) plus treatment as usual vs treatment as usual alone.
- Main outcome: depression (Hamilton Depression Rating Scale score).
- Funding: Michael J. Fox Foundation for Parkinson’s Research; Parkinson’s Alliance.
- Unknown generalizability to patients with more severe Parkinson disease, dementia.
- Nonspecific factors, such as attention, may have influenced benefit.
- Relative contribution of intervention components is unclear.