- Results from a small randomized clinical trial (RCT) suggest that parathyroidectomy is associated with reduced total cholesterol levels, but increased ambulatory diastolic blood pressure in patients with primary hyperparathyroidism (PHPT).
Why this matters
- Associations between primary hyperthyroidism, thyroidectomy, and CVD risk have varied in previous studies.
- Plasma total cholesterol levels were reduced in patients who received parathyroidectomy compared with control patients (−0.24% vs +5.25%; P=.04).
- 24-hour diastolic blood pressure was increased in patients who received parathyroidectomy compared with control patients (+0.51% vs −3.40; P=.03).
- Parathyroidectomy was significantly associated with decreased pulse wave velocity (a marker for arterial stiffness) compared with no parathyroidectomy in patients with ionized calcium ≥1.45 mmol/L (−4.4% vs +3.0%; P=.02), but not in the entire group (P>.05).
- 79 patients with primary hyperparathyroidism, 40 who received parathyroidectomy and 39 control subjects, were included.
- Funding: None.
- Small patient sample size.
- Patients with severe hypercalcemia excluded.
- Short follow-up.