Physical activity effects on LUTS remain uncertain: Cochrane

  • Silva V & al.
  • Cochrane Database Syst Rev
  • 6 Apr 2019

  • International Clinical Digest
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Takeaway

  • The therapeutic effects of physical activity on lower urinary tract symptoms secondary to benign prostatic obstruction (LUTS/BPO) are uncertain.

Why this matters

  • Patients, providers, and policy makers considering this intervention for LUTS/BPO should recognize the quality of supporting evidence is very low.

Study design

  • Researchers reviewed 6 randomized clinical trials (RCTs) including men with moderate or severe LUTS (N=652; aged >40 years), using the Cochrane Handbook for Systematic Reviews of Interventions.
  • Funding: Centro Universitário Tiradentes; Universidade Estadual de Mato Grosso do Sul; Universidade Federal de São Paulo; Coppin State University.

Key results

  • For RCTs comparing physical activity vs watchful waiting, effects were uncertain for:
    • LUTS score, mean difference (MD), −8.1 (95% CI, −13.2 to −3.1).
    • Response rate, risk ratio (RR), 1.80 (95% CI, 0.81-4.02).
    • Withdrawal because of adverse events, RR: 1.00 (95% CI, 0.59-1.69).
  • For those comparing physical activity vs alpha‐blockers, effects were uncertain for:
    • LUTS score, MD, 2.8 (95% CI, −0.9 to 6.4).
    • Response rate, RR, 0.80 (95% CI, 0.55-1.15).
    • Withdrawal because of adverse events, RR, 0.86 (95% CI, 0.06-12.89).

Limitations

  • Few RCTs were available for analysis; all had small sample sizes and very low evidence quality.

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