Physical activity tied to reduced CV events regardless of BP status

  • Joseph G & al.
  • Hypertension
  • 14 Oct 2019

  • International Clinical Digest
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Takeaway

  • Physical activity shows a dose-response benefit against cardiovascular (CV) events and all-cause mortality regardless of BP status (normal, elevated, hypertensive).

Why this matters

  • The right balance of exercise in terms of its CV protection for patients with hypertension has been elusive.
  • These results suggest that more exercise yields greater benefit, even with hypertension.

Key results

  • Compared with no activity, for patients with stage I hypertension, risk (adjusted HR; 95% CI) for all-cause mortality was:
    • Light activity: 0.78 (0.72-0.84; P<.001>
    • Moderate-high activity: 0.69 (0.63-0.75; P<.001>
  • CV event risk reductions were similar.

Study design

  • Prospective study that included 18,974 people, ages 20-98 years; mean follow-up, 23.4±11.7 years.
  • Activity was self-reported.
  • Hypertension threshold in this study was 90-99/140-159 mmHg.

Limitations

  • Population was all white.

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