Physical, mental health affect survival benefit after lung cancer surgery

  • Clin Lung Cancer

  • curated by Kelli Whitlock Burton
  • Univadis Clinical Summaries
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Takeaway

  • Declines in the ability to perform activities of daily living (ADL) and mental health-related QoL are significantly associated with worse survival among older patients after surgery for lung cancer.

Why this matters

  • Identifying patients at risk for these declines before surgery could guide a treatment plan that includes interventions aimed at addressing these issues.

Study design

  • 138 patients aged ≥65 years with a first diagnosis of lung cancer, 1998-2014.
  • Follow-up at 20 months after surgery.
  • Funding: None.

Key results

  • Median age at diagnosis was 74 years.
  • 27% of patients had a decrease in Katz ADL scores at follow-up (P<.0001>
  • 57% reported a significant decline in physical health-related QoL (P<.0001>
  • 45% reported a decline in mental health-related QoL at follow-up, but the change was not statistically significant (P=.07).
  • The number of days of poor physical health significantly increased between baseline and follow-up (5.1±8.7 vs 10.2±13.8 days; P<.0001>
  • After multivariable analysis, a decline in Katz score was significantly associated with worse OS (adjusted HR, 1.78; P=.02). 
  • In addition, a decline in mental health-related QoL was associated with worse disease-specific OS (adjusted HR, 2.11; P=.02).

Limitations

  • Retrospective.