Plasma zinc level tied to first stroke risk in patients with hypertension

  • Zhang J & al.
  • Stroke
  • 26 Aug 2019

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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Takeaway

  • This study found an inverse association between baseline plasma zinc levels and the risk for haemorrhagic stroke in patients with hypertension.
  • This association was stronger in those with higher body mass index (BMI) and lower plasma copper levels.

Why this matters

  • The findings, if further confirmed, may inform clinical and nutritional research on haemorrhagic stroke by considering zinc as a potentially variable risk factor, particularly in obese patients or those with low plasma copper levels

Study design

  • This nested case-control study included 599 first stroke cases and 599 matched controls with complete zinc measurements from the China Stroke Primary Prevention Trial (CSPPT, n=20,702).
  • Outcomes included the first stroke and its sub-types (first ischaemic and haemorrhagic stroke).
  • Funding: National Key Research and Development Program and others.

Key results

  • The risk for first haemorrhagic stroke was significantly lower in participants with plasma zinc ≥106.9 μg/dL vs those with baseline plasma zinc
  • The inverse association of plasma zinc levels with first haemorrhagic stroke was significantly stronger in participants with (Pinteraction<.05 for all style="list-style-type:circle;">
  • BMI ≥25.0 kg/m2, or
  • plasma copper level
  • Plasma zinc levels demonstrated no significant association with:
    • first total stroke (
    • first ischaemic stroke (
  • Limitation

    • Post-hoc analysis.
    • Risk for residual confounding.

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