- This study found an inverse association between baseline plasma zinc levels and the risk for haemorrhagic stroke in patients with hypertension.
- This association was stronger in those with higher body mass index (BMI) and lower plasma copper levels.
Why this matters
- The findings, if further confirmed, may inform clinical and nutritional research on haemorrhagic stroke by considering zinc as a potentially variable risk factor, particularly in obese patients or those with low plasma copper levels
- This nested case-control study included 599 first stroke cases and 599 matched controls with complete zinc measurements from the China Stroke Primary Prevention Trial (CSPPT, n=20,702).
- Outcomes included the first stroke and its sub-types (first ischaemic and haemorrhagic stroke).
- Funding: National Key Research and Development Program and others.
- The risk for first haemorrhagic stroke was significantly lower in participants with plasma zinc ≥106.9 μg/dL vs those with baseline plasma zinc
- The inverse association of plasma zinc levels with first haemorrhagic stroke was significantly stronger in participants with (Pinteraction<.05 for all style="list-style-type:circle;">
- BMI ≥25.0 kg/m2, or
- plasma copper level
- first total stroke (
- first ischaemic stroke (
- Post-hoc analysis.
- Risk for residual confounding.