- Higher genetic risk score (GRS) and positive family history are associated with significant risk for prostate cancer (PCa).
Why this matters
- Combining family history and GRS can improve patient stratification and screening strategies.
- Secondary analysis of 3225 men (aged 50-75 years) from randomized, double-blind, placebo-controlled, 4-year REDUCE trial.
- The GRS was calculated using established PCa risk-associated single nucleotide polymorphisms.
- Funding: National Cancer Institute.
- PCa detection rate by GRS risk group:
- 14%, 22%, and 32% in low-, average-, and high-GRS risk groups, respectively (P-trend<.001>
- PCa detection rate was 27% in men with family history vs 21% in those without (P=.02).
- PCa diagnosis-free survival (PDFS) was worse in:
- Men in the higher GRS risk group (χ2=53.3; P-trend<.001>
- Men with family history of PCa vs no history (73 vs 77 years; χ2=0.59; P<.001>
- May not be generalizable to non-European men.