- Polypharmacy is associated with an increased risk for dementia.
Why this matters
- Clinicians should be careful when prescribing drugs in older patients to avoid unnecessary polypharmacy and potentially inappropriate medications.
- Average number of drugs prescribed to patients with dementia 2 y before diagnosis was 2.54 vs 1.75 for control patients.
- Polypharmacy was more common in patients with dementia (18.8%) compared with in control patients (10.8%).
- Patients with dementia were more likely to be prescribed a potentially inappropriate medication than control patients (OR, 1.5-2.0).
- Nested case-control study of 5562 patients newly diagnosed with dementia and control patients followed for 12 y.
- Funding: National Research Foundation of Korea, Korean government.
- Data came from insurance claims, so the researchers did not have access to full medical records.