Pooled analysis nixes link between blood transfusions, NHL

  • Cerhan JR & al.
  • Cancer Causes Control
  • 4 Jun 2019

  • curated by David Reilly
  • Univadis Clinical Summaries
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Takeaway

  • A large pooled analysis investigating an association between blood transfusion history and risk of non-Hodgkin lymphoma (NHL) found mixed results and concluded that no such significant association exists.

Why this matters

Study design

  • Pooled analysis to investigate an association between blood transfusion and risk of NHL, based on 13 case-control studies in the InterLymph Consortium.
  • Pooled population comprised 10,805 NHL cases and 14,026 controls.
  • Funding included: British Columbia study: Canadian Institutes for Health Research, Canadian Cancer Society, and Michael Smith Foundation for Health Research.

Key results

  • Inverse association between transfusion history and risk of NHL for men (OR, 0.75; 95% CI, 0.67-0.84) but not for women (OR, 0.94; 95% CI, 0.85-1.04); the difference was statistically significant (P=.014), largely driven by non-Hispanic whites and not observed in other racial/ethnic groups.
  • Association varied by study design in terms of risk estimates in men and women and in hospital-based and population-based studies.
  • No trend with number of transfusions, time since first transfusion, age at first transfusion, or decade of first transfusion; findings were not altered by further adjustment for socioeconomic status, BMI, smoking, alcohol use, and HCV+ status.

Limitations

  • Retrospective data.