- Sleeping for short periods or in fragmented bits increases risk for subclinical atherosclerosis in middle-aged people.
Why this matters
- This study ties sleep duration and quality directly to risk.
- Editorial notes the link with an objective finding as an important result but says the study still “sheds little light” on mechanisms.
- Higher atherosclerotic burden was seen with very short sleep:
- OR, 1.27 (95% CI, 1.06-1.52; P=.008).
- Fragmented sleep (highest quintile) enhanced risk for multiple affected areas:
- OR, 1.34 (95% CI, 1.09-1.64; P=.006).
- 10- and 30-year Framingham risk scores were higher with very short or short sleep durations.
- Coronary artery calcification scores did not associate with sleep pattern.
- Respondents with very short sleep durations tended to have higher daily alcohol and caffeine intakes.
- Participants tended to overestimate sleep duration in self-report vs accelerometer findings.
- 3974 participants (4 groups: very short sleep,
- Carotid, femoral 3D ultrasound, cardiac CT performed.
- Funding: Centro Nacional de Investigaciones Cardiovasculares, Spain; others.
- Homogeneous population, middle-aged participants only.