Poor sleep linked to Crohn's disease activity and complication risk

  • Sofia MA & al.
  • Inflamm Bowel Dis
  • 10 Dec 2019

  • International Clinical Digest
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Takeaway

  • Poor sleep quality may identify patients with Crohn's disease who are at risk for disease activity and complications.

Why this matters

  • "Addressing sleep quality may be an opportunity to improve not only quality of life but also clinical outcomes," say researchers.

Study design

  • Researchers studied patients with CD both with and without poor sleep (N=92; mean age, 42.9 [range, 18-82] years; 62% women), exploring the correlation between scores from the Pittsburgh Sleep Quality Index (PSQI) and Harvey-Bradshaw index (HBI) of CD activity, as well as between PSQI score and risk for hospitalisation or surgery.
  • Funding: NIH.

Key results

  • 77% patients with CD had PSQI >5.
  • PSQI scores correlated with HBI scores (rho=0.256; P=.014) at baseline, as did changes in these scores after 1 year (rho=0.47; P=.002).
  • These patients reported more night awakenings because of pain and bathroom use.
  • Cox regression showed that PSQI >8 predicted surgery or hospitalisation (HR, 5.37; 95% CI, 1.39-27.54)

Limitations

  • The study was observational and single-centre with a small sample size; it did not assess causality.

—Craig Hicks