- Positive HBV surface antigen (HBsAg+) serology is associated with a modest increased risk for chronic kidney disease (CKD), according to data from a large population study.
Why this matters
- Korean study of 299,913 adults (mean age, 37.3±7.9 years); 3.7% (n=11,209) were HBsAg+.
- CKD defined as estimated glomerular filtration rate (eGFR, in mL/minute/1.72 m2)
- Funding: None.
- Mean follow-up, 5.6 years (1,673,701 person-years [PY]).
- 13,924 incident cases of CKD reported (incidence rate, 8.3/1000 PY).
- Proteinuria: 11,072 cases (incidence rate, 6.6/1000 PY).
- CKD incidence rate was higher in HBsAg+ vs HBsAg– patients (9.3 vs 8.3/1000 PY).
- HBsAg+ serology was tied to an 11% increased risk for incident CKD (HR=1.11; P=.01).
- Effect driven by proteinuria (HR=1.23; P<.001 not egfr>
- Results were consistent after excluding patients treated for viral hepatitis, and in sensitivity analysis excluding those with liver cirrhosis or HCV+ serology.
- Proteinuria detected by dipstick test.
- Limited follow-up (young population).
- Viral load, use of nephrotoxic agents not captured.