- Consider oral glucose tolerance test (OGTT) in patients with coronary artery disease (CAD) without known diabetes because the test predicts CAD severity.
Why this matters
- Postprandial hyperglycemia influences cardiovascular disease.
- Standard 75-g OGTTs performed and fasting plasma glucose (FPG) measured 2-4 weeks after hospital discharge in 240 patients admitted for coronary angiography because of angina and compared with 26 healthy control patients.
- CAD severity was graded using the Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX) and Jeopardy scoring systems.
- Funding: National Science Council; Taichung Veterans General Hospital, Taiwan.
- SYNTAX score was positively correlated with 2-hour OGTT (r, 0.164; P<.05 and serum creatinine but not with systolic bp high-density lipoprotein triglycerides waist circumference or fpg.>
- Jeopardy score also positively associated with 2-hour OGTT (r, 0.187; P<.01 but not fpg.>
- SYNTAX and Jeopardy scores were higher in patients with 2-hour glucose ≥140 mg/dL vs
- Neither score differed significantly between patients with FPG ≥100 mg/dL vs not significant).
- Both scores independently associated with 2-hour OGTT after adjustment for confounders.
- Cross-sectional, single-center study.
- Patients agreeing to postdischarge OGTT may practice better self-care.
- Controls and patients not matched.
- All-Asian study population.