- Cerebral hyperoxia burden within the first 96 hours after birth was associated with an increased risk for severe retinopathy of prematurity (ROP).
Why this matters
- Findings suggest that cerebral oxygen saturation (rcSO2) may be more sensitive to detect the risk for severe ROP than arterial oxygen saturation (SaO2) in early infancy.
- Retrospective analysis of 225 preterm infants born ≤30 weeks’ gestation (median gestational age, 28.0 weeks; mean birth weight, 1032 g) and admitted to the neonatal intensive care unit.
- Burden of cerebral and arterial hyperoxia (defined as the percentage of time spent at saturation thresholds exceeding 85% and 90%, respectively) was calculated.
- Funding: Junior Scientific Master Class of the University of Groningen.
- Overall, 30 infants developed mild ROP and 8 developed severe ROP.
- Infants with severe ROP vs those without had a higher burden of cerebral hyperoxia (30%; interquartile range [IQR], 3-76% vs 16%; IQR, 5-33%).
- On day 2, infants with severe ROP vs those without spent more time at cerebral hyperoxic levels (53% vs 17%).
- Every 10% more time spent above a rcSO2 threshold of 85% during the first 4 days after birth, the risk for severe ROP was doubled (OR, 1.50; 95% CI, 1.09-2.06; P=.013).
- No association was observed between the burden of arterial hyperoxia and ROP.
- Retrospective design.
- Small sample size.