Women with pre-eclampsia and no major comorbidities before their first pregnancy are at an almost five-fold increased risk of end-stage kidney disease (ESKD) compared with parous women with no pre-eclampsia, according to a new research.
The study, published in PLOS Medicine, examined the association between pre-eclampsia and the risk of ESKD in 1,366,441 healthy women in Sweden, while taking into account pre-existing comorbidity and potential confounders. The women had 2,665,320 singleton births between them between 1982 and 2012.
During the study period, 67,273 women with 74,648 singleton live births had pre-eclampsia.
A total 410 women developed ESKD with an incidence rate of 1.85 per 100,000 person-years among women with no pre-eclampsia and 12.35 among women who had pre-eclampsia.
In adjusted analysis, the authors identified an almost five-fold association between pre-eclampsia and ESKD (hazard ratio [HR] 4.96; 95% CI 3.89-6.32; P<.001 women who had preterm pre-eclampsia and in two pregnancies the highest risk of eskd compared with no they found.>
While the authors noted the absolute risk of ESKD among women with pre-eclampsia remains small, they said pre-eclampsia should be considered an important risk factor for subsequent ESKD with further study warranted on preventative interventions.