- Women with preeclampsia have a higher risk for Alzheimer's disease and other dementias later in life.
- Highest risk is for vascular dementia.
Why this matters
- Women with preeclampsia have a higher risk for endothelial and vascular dysfunction that persists after pregnancy and can result in later hypertension, cardiovascular disease, stroke, and diabetes.
- Early identification of people at risk for dementia may provide an opportunity to delay or prevent disease.
- Obstetrical history should be part of a complete medical history.
- Women with a diagnosis of preeclampsia had a 53% increased risk of overall dementia (HR, 1.53; 95% CI, 1.26-1.85).
- Recurrent preeclampsia increased risk for dementia (HR, 1.44; 95% CI, 1.17-1.76).
- Women with preeclampsia had more than 3-fold increased risk for vascular dementia (HR, 3.46; 95% CI, 1.97-6.10).
- Women with preeclampsia had an increased risk for Alzheimer's disease (HR, 1.45; 95% CI, 1.05-1.99).
- Nationwide register-based cohort study in Denmark between 1978 and 2015 (n≥1.1 million pregnant women).
- Women with preeclampsia (n=58,410) compared with controls (n=1,119,595).
- Dementia was identified using ICD codes.
- Funding: The Danish Council for Independent Research.
- Dependent upon completeness of register data.