Preeclampsia is a risk factor for Alzheimer's, other dementias

  • BMJ

  • curated by Elisabeth Aron, MD, MPH, FACOG
  • Clinical Essentials
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Women with preeclampsia have a higher risk for Alzheimer's disease and other dementias later in life.
  • Highest risk is for vascular dementia.

Why this matters

  • Women with preeclampsia have a higher risk for endothelial and vascular dysfunction that persists after pregnancy and can result in later hypertension, cardiovascular disease, stroke, and diabetes.
  • Early identification of people at risk for dementia may provide an opportunity to delay or prevent disease.
  • Obstetrical history should be part of a complete medical history.

Key results

  • Women with a diagnosis of preeclampsia had a 53% increased risk of overall dementia (HR, 1.53; 95% CI, 1.26-1.85).
  • Recurrent preeclampsia increased risk for dementia (HR, 1.44; 95% CI, 1.17-1.76).
  • Women with preeclampsia had more than 3-fold increased risk for vascular dementia (HR, 3.46; 95% CI, 1.97-6.10).
  • Women with preeclampsia had an increased risk for Alzheimer's disease (HR, 1.45; 95% CI, 1.05-1.99).

Study design

  • Nationwide register-based cohort study in Denmark between 1978 and 2015 (n1.1 million pregnant women).
  • Women with preeclampsia (n=58,410) compared with controls (n=1,119,595).
  • Dementia was identified using ICD codes.
  • Funding: The Danish Council for Independent Research.

Limitations

  • Dependent upon completeness of register data.

Please confirm your acceptance

To gain full access to GPnotebook please confirm:

By submitting here you confirm that you have accepted Terms of Use and Privacy Policy of GPnotebook.

Submit