- Women with preeclampsia are at risk for chronic renal disease.
Why this matters
- Complications during pregnancy may predict health risks.
- Women with preeclampsia may benefit from close monitoring for kidney disease, especially in the first 5 years after delivery.
- Women with a diagnosis of preeclampsia had twice the risk of developing later chronic renal disease overall compared with women who delivered at the same gestational age without preeclampsia.
- Associations between preeclampsia and chronic renal disease were stronger for women with preeclampsia at an earlier gestational disease (HRs; 95% CIs):
- Early preterm: 3.93 (2.90-5.33);
- Late preterm: 2.81 (2.13-3.71); and
- Term: 2.27 (2.02-2.55).
- Risk was highest in the first 5 years after pregnancy: HR 6.11 (95% CI, 3.84-9.72).
- Nationwide register-based cohort study.
- Cohort obtained from the Medical Birth Register and the National Patient Register of Denmark between 1978 and 2015 (n=1,072,330).
- Women with preeclampsia, HELLP (hemolysis, elevated liver enzymes, low platelet count), or eclampsia were identified and followed for 19,994,470 person years (average 18.6 years per woman).
- Funding: Danish Council for Independent Research.
- Definitions of preeclampsia have changed over the years, making it difficult to classify disease.