Preeclampsia linked to later chronic kidney disease

  • BMJ

  • International Clinical Digest
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Takeaway

  • Women with preeclampsia are at risk for chronic renal disease.

Why this matters

  • Complications during pregnancy may predict health risks.
  • Women with preeclampsia may benefit from close monitoring for kidney disease, especially in the first 5 years after delivery.

Key results

  • Women with a diagnosis of preeclampsia had twice the risk of developing later chronic renal disease overall compared with women who delivered at the same gestational age without preeclampsia.
  • Associations between preeclampsia and chronic renal disease were stronger for women with preeclampsia at an earlier gestational disease (HRs; 95% CIs):
    • Early preterm: 3.93 (2.90-5.33);
    • Late preterm: 2.81 (2.13-3.71); and
    • Term: 2.27 (2.02-2.55).
  • Risk was highest in the first 5 years after pregnancy: HR 6.11 (95% CI, 3.84-9.72).

Study design

  • Nationwide register-based cohort study.
  • Cohort obtained from the Medical Birth Register and the National Patient Register of Denmark between 1978 and 2015 (n=1,072,330).
  • Women with preeclampsia, HELLP (hemolysis, elevated liver enzymes, low platelet count), or eclampsia were identified and followed for 19,994,470 person years (average 18.6 years per woman).
  • Funding: Danish Council for Independent Research. 

Limitations

  • Definitions of preeclampsia have changed over the years, making it difficult to classify disease.

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