- Women with preeclampsia have a 5-fold higher risk for later end-stage renal disease (ESRD) compared with women who have never had preeclampsia.
Why this matters
- Earlier stages of renal disease are more common in women than men.
- Reproductive history, including preeclampsia, is hypothesized to play a role.
- Benefit of screening and prevention for reducing ESRD risk is worth more investigation, the authors say, noting the overall low risk.
- Study of 1,366,441 healthy women with 2,665,320 live singleton births, 1982-2012, Sweden.
- Mean age at first pregnancy: 27.8±5.13 years; mean BMI: 23.4±4.03 kg/m2.
- Median follow-up: 7.4 years overall; 16.4 years for women with ESRD.
- Funding: Irish Center for Fetal and Neonatal Translational Research; Swedish Kidney Foundation; others.
- 67,273 women (4.9%) had preeclampsia; 410 developed ESRD.
- Incidence rate was higher among women with vs without preeclampsia: 12.35 vs 1.85 per 100,000 person-years.
- Preeclampsia was tied to a 5-fold risk for ESRD vs no preeclampsia (adjusted [a]HR, 4.96; P<.001 for age bmi smoking other factors>
- Risk for ESRD was highest with:
- Preterm preeclampsia: aHR, 9.19 (P<.001>
- Preeclampsia in 2 pregnancies: aHR, 7.13 (P<.001>
- Observational design.