- Meta-analysis suggests pregabalin can relieve acute and chronic postoperative pain in patients undergoing thoracotomy and decrease the incidence of neuropathic pain and morphine consumption.
Why this matters
- This is the first meta-analysis to evaluate pregabalin as an adjuvant to a perioperative multimodal analgesic regimen in thoracotomy.
- The effectiveness of pregabalin in postoperative pain is controversial.
- Meta-analysis of 9 randomised-controlled trials including 684 patients who received either pregabalin or conventional analgesia/placebo (control group).
- Outcome: Postoperative pain scores and incidence of neuropathic pain.
- Funding: The Medical Science Research Foundation of Zhejiang Province; The Natural Science Fund of Zhejiang Province; other.
- Pregabalin significantly reduced postoperative pain scores at:
- day 1 (mean difference [MD], −0.87; P=.01),
- day 3 (MD, −1.55; P<.00001>
- 1 month (MD, −1.58; P=.008),
- 3 months (MD, −1.69; P=.001).
- the incidence of neuropathic pain by 80% (P=.04) and
- mean morphine consumption (MD, −5.03; P=.001).
- Heterogeneity between studies.