- Exposure to antidepressants and/or anxiolytics during the first 16 weeks of pregnancy tripled the risk for preeclampsia, but cessation of those medications before the 16th week reduced the risk.
- Use of an SNRI or a tricyclic antidepressant increased preeclampsia risk by more than 6- and 7-fold, respectively.
Why this matters
- Nearly 5% of participants were exposed to antidepressants and/or anxiolytics during pregnancy.
- Study of 6878 pregnant women.
- Funding: Canadian Institutes of Health Research.
- 4.9% of women received antidepressant and/or anxiolytic medication (before week 16, 3.16%).
- 2.94% of women developed gestational hypertension and 1.85% developed preeclampsia.
- Women who received antidepressant and/or anxiolytic drugs within week 16 gestation showed higher risk for preeclampsia (aOR, 3.09; P=.001) vs those who did not.
- SNRIs were tied to 6.46-fold risk (aOR, 6.46; P<.0001>
- Risk was not statistically significant in tricyclic antidepressant users (P=.27).
- Significantly higher with continued antidepressant and/or anxiolytic drugs after 16 weeks (aOR, 3.41; P=.001).
- Statistically similar in women who discontinued antidepressant and/or anxiolytic medications before 16 weeks (aOR, 1.60; 95% CI, 0.21-12.34, crossing the unity barrier).
- Small number of antidepressant and anxiolytic users.
Coauthored with Antara Ghosh, PhD