Pregnancy history predicts premature postpregnancy hypertension

  • Egeland GM & al.
  • J Am Heart Assoc
  • 13 May 2018

  • curated by Elisabeth Aron, MD, MPH, FACOG
  • Clinical Essentials
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  • Pregnancy history may predict subsequent hypertension in women.

Why this matters

  • Identification of risk factors may allow for increased monitoring and interventions to reduce the burden of premature cardiovascular disease in women.

Key results

  • Overweight/obese prepregnancy BMI, prepregnancy daily smoking, low educational level, poor diet quality, low physical activity level, and high weight retention at 6 months postpartum were associated with a greater risk for subsequent hypertension.
  • Occasional and weekly alcohol consumption, a greater duration of oral contraceptive use before pregnancy, and breastfeeding daily at 6 months were associated with a decreased risk for subsequent hypertension.
  • Women with pregnancies complicated by preeclampsia (HR, 8.4; 95% CI, 6.49-10.88) or gestational hypertension (HR, 12.07; 95% CI, 9.09-16.03), diabetes mellitus or gestational diabetes mellitus (HR, 3.36; 95% CI, 2.05-5.51), and preterm delivery (HR, 2.19; 95% CI, 1.59-3.02) were more likely to have hypertension within 10 years.

Study design

  • Population-based cohort study.
  • Cohort taken from the Norwegian Mother and Child Cohort Study (MoBa), a prospective population-based pregnancy cohort conducted by the Norwegian Institute of Public Health.
  • Primary outcome was subsequent pharmacologically treated hypertension.
  • Funding: Norwegian Institute for Public Health; University of Bergen.


  • Family history lacking.
  • Homogeneous population; results possibly not generalizable.

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