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Clinical Summary

Pregnant women with vitamin D deficiency at increased risk for UTI

Takeaway

  • Women with low serum vitamin D levels (<20 ng/mL) were at higher risk for urinary tract infections (UTIs) during pregnancy.

Why this matters

  • The prevalence of UTI during pregnancy is high.
  • Findings suggest that vitamin D supplementation may be useful for the prevention of UTIs.

Study design

  • Case-control study included 97 pregnant women with UTIs (case group) and 90 healthy pregnant women (control group).
  • Vitamin D levels were classified according to recent Clinical Guidelines Committee as follow:
    • deficiency (<20 ng/mL),
    • insufficiency (21-29 ng/mL), and
    • sufficiency (30-100 ng/mL).
  • Funding: School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Key results

  • Vitamin D deficiency was reported in 85.7% of case group and 52.2% of control group
  • Pregnant women with UTIs had significantly lower serum vitamin D levels compared with the control group (12.7±5.9 vs 26.05±10.37 ng/mL; P<.001).
  • Serum vitamin D levels were significantly lower in pregnant women with UTIs and acute pyelonephritis vs those with Cystitis (11.06±7.53 vs 13.94±5.44 ng/mL; P=.020).
  • After adjustment for confounders, low serum vitamin D level (<20 ng/mL) was significantly associated with the increased risk for UTIs in pregnant women (adjusted OR, 3.67; 95% CI, 1.19-6.24; P<.001).

Limitations

  • Possibility of inaccuracy in responses regarding the frequency of sexual intercourse by participants.

References


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