Premenopausal cardiovascular disease before age 35 years tied to higher risk of menopause before age 45 years

  • Zhu D & al.
  • Eur J Epidemiol
  • 5 Feb 2019

  • curated by Sarfaroj Khan
  • UK Medical News
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According to a study, published in the journal European Journal of Epidemiology, premenopausal cardiovascular disease (CVD) before age 35 years is associated with 2-fold increased risk for early menopause (age,

Researchers evaluated 177,131 women from 9 studies who had either experienced no premenopausal CVD event or had experienced a premenopausal CVD event before age 50 years to determine the association between age at onset of premenopausal CVD events (coronary heart disease [CHD] and stroke) and age at natural menopause.

Overall 1561 (0.9%) premenopausal women reported CVD including CHD (n=1130) and stroke (n=469) at a mean age of 41.3 years. Women who experienced a first CVD event before age 35 years had a 2-fold increased risk for early menopause (CVD: adjusted relative risk ratio [aRRR], 1.92; 95% CI, 1.17-3.14; CHD: aRRR, 1.86; 95% CI, 1.01-3.43 and stroke: aRRR, 2.17; 95% CI, 1.43-3.30). Women who experienced a first premenopausal CVD event after age 40 years were more likely to experience natural menopause at around 51 years.

Authors suggested, “Further studies are warranted to determine a possible association between measures of vascular damage and age at natural menopause. Additionally, women experiencing a CVD event before 35 years of age should be warned for their future high possibility of having early menopause.”