- Preoperative carcinoembryonic antigen (CEA) levels >10 ng/mL are associated with worse survival in patients with stage I-III colorectal cancer (CRC) undergoing curative-intent resection.
- 5-year survival was similar between patients with negative lymph node staging and CEA >10 ng/mL and those with positive lymph node staging and CEA ≤5 ng/mL.
Why this matters
- The results suggest that patients with negative lymph node stage and CEA >10 ng/mL are candidates for intense follow-up and/or adjuvant chemotherapy.
- Retrospective propensity-score analysis of 6099 patients with stage I-III CRC.
- Funding: Chang Gung Medical Research Fund.
- A propensity score analysis showed higher mortality associated with higher CEA levels compared with CEA ≤5 ng/mL:
- CEA 5-10 ng/mL: OS (comparison to CEA ≤5 ng/mL; HR, 1.376), cancer-specific survival (CSS; HR, 1.404), recurrence-free interval (RI; HR, 1.190; P<.01 for all>
- CEA >10 ng/mL: OS (HR, 1.523), CSS (HR, 1.712), and RI (HR, 1.468; P<.01 for all>
- Retrospective, single-center analysis.