- Women with cardiovascular (CV) hemodynamic dysfunction before pregnancy may be at risk for preeclampsia and/or fetal growth restriction (FGR).
Why this matters
- CV hemodynamic dysfunction may be responsible for the development of preeclampsia and FGR.
- Identifying women at risk for preeclampsia/FGR may help to prevent some adverse pregnancy outcomes.
- 6.8% of cohort had preeclampsia/FGR.
- Preconception cardiac output (4.9 vs 5.8 L/minute; P=.002), cardiac index (2.9 vs 3.3 L/minute/m2; P=.031), and stroke volume (73.9 vs 82.2 mL; P=.047) were lower in women with preeclampsia/FGR.
- Total peripheral resistance (1396.4 vs 1156.1 dynes·second·cm−5; P<.001 and mean arterial pressure vs mmhg p=".04) were" higher in women with preeclampsia>
- Prospective cohort study of healthy women intending to conceive (n=530).
- CV hemodynamic assessments were performed and women followed up until conception (n=356).
- Singleton pregnancies without complications received multiple hemodynamic assessments during pregnancy (n=218).
- Funding: National Institute for Health Research Imperial BRC; Imperial College Healthcare Charity.
- Small number of patients with preeclampsia/FGR.
- Selection bias is possible.