Pretreatment total T predicts effects of tadalafil on BOO

  • Matsukawa Y & al.
  • Aging Male
  • 16 Jan 2019

  • curated by Craig Hicks
  • Clinical Essentials
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Takeaway

  • The therapeutic effects of tadalafil (Cialis) for bladder outlet obstruction (BOO) can be predicted based on pretreatment total testosterone (TT) level.

Why this matters

  • This finding could help clinicians selecting a therapeutic strategy for patients with lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH).

Study design

  • Researchers studied outpatients with LUTS due to BOO, treating them with 5 mg tadalafil daily for 12 months (n=69; mean age, 69.8 years; mean prostate volume, 48.8 mL).
  • They then separated patients into good and poor responders, based on improvements in BOO index (BOOI).
  • Funding: None disclosed.

Key results

  • After 12 months, mean BOOI in good responders (30 patients or 43.5%) improved from 71.8 to 39.3 (P<.001>
  • Mean BOOI in poor responders (39 patients or 56.5%) only changed from 70.6 to 64.3 (P=.25).
  • Pretreatment TT was the only independent predictor related to improvements in BOO (R=0.33; P=.003).

Limitations

  • The study was single-center and open-label, with a small sample size.

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